• Unexplained infertility refers we don’t know why the couple is infertile.
• It is a limitation of our today s diagnostic medical knowledge.
• Infertility may be said to be unexplained if the woman is ovulating regularly has open fallopian tubes with no adhesions or endometriosis.
• If the man has normal sperm production & the post-coital test is positive.
• Intercourse must take place frequently particularly around the time of ovulation and the couple must have been trying to conceive for at least 1 year.
• 10% of all infertile couple have unexplained infertility.

Diagnosis –

• The diagnosis of unexplained infertility should consider only after all the tests have been performed & their result found to be normal.
• The frequency of this diagnosis will depend upon how many tests are done by the clinic. The fewer the tests the more frequent the diagnosis.

Possible cause of unexplained infertility –

Tubal Abnormalities

• It is possible that there may be a subtle defect in the mechanism by which the fimbria pick up the egg at ovulation.
• The cilia in the tube may not function properly.
• Tubal secretions may be improper or defective or not sperm friendly or not embryo friendly or embryo nutritive.
• The environment of the tube may not be optimum at the timing of ovulation.

Defective ovum

• Persistent production of the abnormal ovum.
• Ovum might be with the deformed structure or chromosomal abnormalities.
• Defective zona pellucida of ovum for acrosomal procedure.
• Directivity in respectively of an ovum with a particular structure of sperm.

Trapped eggs

• In some cases, eggs are produced & mature correctly within the follicle which then goes into becoming a corpus luteum without however first bursting to release the egg.
• The egg is therefore effectively trapped inside the unbroken corpus luteum called a luteinized unruptured follicle syndrome.

Luteal phase Abnormalities –

• Day of ovulation to day 1 is known as the luteal phase.
• It may be short duration or inadequate & this is called luteal phase defect.
• The hormone progesterone is essential for preparing the endometrium to receive the fertilized egg ( embryo ).
• The progesterone production rising is too slow or level might be very low may lead to defective endometrium and affect the endometrium receptivity.
• This condition is known as luteal phase abnormalities.
• Perfect diagnosis of lutead phase abnormalities is not possible.

Immunological factors –

• The Immune system can react against the man’s sperm & kill them immobilize them or make them stick together.
• Women can also develop an immune reaction to the coating of their ovum eggs which can prevent fertilization of the ovum.
• Women s immune system can prevent her embryos from implanting in the uterus.

Infection –

• Certain undetectable infection of mycoplasma or chlamydia may be present in person may lead to unexplained infertility.

The inability of sperm to penetrate eggs & defective CS 1 protein

• Some men have complete normal sperm count with good motility but sperm is defective with an acrosomal enzyme can not give Acrosomal reaction with the ovum.
• Sperm defective in CS 1 protien (clevange signel 1 protien)is not started clevange cell divison after fertilization.
• Strong CS 1 protein is necessary for initiation of cell division & continuity of development of the embryo.
• IVF goes fail in case of CS 1 protein defective sperm, even after successful ICSI.

Uterine factors

• Some defective intrauterine protein is also responsible .
• Some women have an abnormal endometrium which does not allow the embryo to implant, in this kind of case IVF goes to fail. It is difficult to diagnosis.
• In some unfertile women, the endometrium remains persistently thin.
• This may be because of inadequate uterine blood flow or poor estrogen receptors in the endometrial cells.

Psychological factors –

• Stress & anxiety produce more production of cortisol hormones & it leads to defective or low-quality ovulation.
• So stress & anxiety might because of infertility in many cases.

Improper sexual intercourse –

• Sexual intercourse at long intervals associated with weak and less motile sperm in semen. This condition is also responsible for unexplained infertility.
• The regular sexual activity is necessary.

Defective cervical mucus –

• Cervical mucus is much more important to improve the capacity of sperm & easy passage of sperm from the vagina to uterus.
• Sticky & thick cervical mucus is a barrier for sperm. Thin & good quality cervical mucus increase the change of conceiving.

Micro endometriosis & fibrosis –

• In the female genital organ, there is a chance of micro endometriosis or fibrosis which cannot be detected by gross inspection by laparoscopy.
• This kind of condition is also responsible in some case of unexplained infertility.

Homeopathy for unexplained infertility –

• Homeopathic treatment has good scope to treat unexplained infertility.
• Constitutional homeopathic treatment helps a lot & it is far superior then the technology of making a diagnosis.
• Most infertile couples are not really interested in the diagnosis of what the problem is – they are much more interested in finding the solution to their problem – getting a child.
• Higher potency homeopathic medicine are very useful when prescribed after individual research & deep case study.